Topic

Butyrate & Gut Microbiota Modifications: Impact on Alzheimer's Disease and Mild Cognitive Impairment.

Summary 

It is a great pleaser to welcome Dr. Kazuo Yamashiro at Tokyo Microbiota 2025 to highlight a strategic topic : Butyrate.

Neuroinflammation plays a key role in the progression of Alzheimer’s disease (AD), and free water (FW) imaging, which measures extracellular water content, serves as a marker for this process. Our recent study highlights a potential gut-brain axis in AD, where neuroinflammation (measured by FW) is linked to gut dysbiosis and reduced butyrate producers. The findings suggest that targeting the gut microbiota, possibly through dietary or probiotic/prebiotic interventions, could be a new therapeutic strategy to mitigate neuroinflammation in AD.

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