Yuji Naito - First Conjoint Meeting ISM – RIKEN on Targeting Microbiota

Topic

Dr. Naito will talk about "Insights into the Microbiota-Gut-Brain Axis from Longevity Research" during our First Conjoint Meeting between ISM and RIKEN, which will take place from October 8-9 in Tokyo, Japan.

Summary

Dr. Naito presentation will provide an overview of the current findings on the microbiota-gut-brain axis, incorporating gut microbiota metabolite analysis, to elucidate potential mechanisms underlying longevity and cognitive health in the unique population Kyotango, Japan.

Kyotango, Longevity and Microbiota

Located two and half hours north of Kyoto City, the rugged Kyotango region is home to an intriguing local secret: the residents of the idyllic fishing villages and mountain hamlets in this backwoods region consistently live longer than Japanese citizens elsewhere. Often remaining genki (energetic) after a century of countryside living, Kyotango residents attribute their longevity to a combination of local benefits. Recent scientific studies have confirmed that the blessings of the northern Kyoto lifestyle are no urban legend, and now travelers can come experience these natural boons for themselves.

Kyotango is renowned for its high concentration of centenarians, boasting approximately 2.8 times more individuals aged 100 or older than Japan’s national average.

Several factors contribute to this remarkable longevity:

1. Diet: The traditional Kyotango diet emphasizes fresh seafood, fermented foods like miso, and locally sourced produce. These dietary habits promote beneficial gut bacteria, which have been linked to improved health and extended lifespan.

2. Active Lifestyle: Residents maintain physical activity through daily routines and engagement with the natural environment, such as walking along the scenic coastline and participating in community activities.

3. Social Engagement: Strong community bonds and regular social interactions provide emotional support and mental stimulation, contributing to overall well-being.

4. Natural Environment: The region’s clean air, access to natural hot springs (onsen), and serene landscapes offer both physical and mental health benefits.

Collectively, these factors create a lifestyle that supports health and longevity, making Kyotango a focal point for studies on aging and well-being.

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